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. 2021 Sep 16;13(9):661. doi: 10.3390/toxins13090661

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of BV on infiltration of neutrophil in gouty rat. (A) Representative hematoxylin and eosin (H&E) stained sections of ankle joint from normal, MSU only, MSU with BV, and MSU with Col treated group. Purple dots represent neutrophils infiltration. Bottom panels are a high magnification of boxed area in the upper panels, which is synovial tissue of ankle joint. Scale bars, 50 μm. (B) Immunohistochemistry for myeloperoxidase (MPO) in ankle joint from normal, MSU only, MSU with BV, and MSU with Col treated group. MPO-positive neutrophils were observed in MSU injected rat ankle joint. Note that both BV and Col treatment decreased neutrophil recruitment. Scale bars, 50 μm.