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Schematic diagram of HSV genome. The genome consists of unique long (UL) and short (US) sequences bracketed by terminal (TRL and TRS) and internal (IRL and IRS) inverted repeat (IR) sequences. The number of a sequence repeats (a, in gray) is variable. Genes relevant for tumor-specificity are shown as colored boxes and their names are indicated above the genome line; the gene product names are indicated below the genome line. Arrows indicate the direction of transcription.
