Figure 3.
Retrovirus sequence comparison. The immature IP6 binding site in Lentiviruses in the MHR and CACTDSPNC region (immature) and CA helix 1 (mature). Lys (K) and Arg (R) residues that are at or near known IP6 binding sites are in red. Simplified morphologies shown are on the right; conical, spherical, cylindrical, nested cores (layering). A minimum of one sequence is displayed for each retrovirus. * = retroviruses with reported IP6-related phenotypes. Italics = endogenous retroviruses. Underlined = retroviruses with solved structures with an IP6 interaction. Underlined amino acid sequences correspond to known alpha-helical structures.