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. 2021 Sep 21;14:4839–4858. doi: 10.2147/JIR.S321513

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© 2021 Li et al.

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Silencing of the AIM2 gene or degradation of NET DNA alleviates alveolar macrophage pyroptosis. Silencing of the AIM2 gene or degradation of NET DNA decreased (A) LDH release, (B and D) intracellular pyroptosome formation, (C) cleaved caspase-1 and IL-1β production and (E) ASC oligomerization. Administration of AIM2 siRNA and degradation of NET DNA also reduced (F) IL-1β, IL-18, and (G) IL-6 and TNF-ɑ levels in the supernatant. (**p<0.01, ****p<0.0001).

Abbreviations: NETs, neutrophil extracellular traps; AMs, alveolar macrophages; LPS, lipopolysaccharide; ASC, apoptosis-associated speck-like protein; IL-1β, interleukin-1β; C/T, current NETs-DNA/total NETs-DNA; LDH, lactate dehydrogenase; AIM2, absent in melanoma 2.