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The mice were injected intradermally with different venom levels of 0.5, 0.33, 0.22, 0.148, and 0.098 µg/g after 72 h. We removed the dorsal skin, and biopsy was performed with HE staining. (A): Dorsal necrotic lesion (B): The inside of the necrotic lesion (C): The mice were intradermally injected with deNTXs (0.22 µg/g). A diffuse distribution and loose organizational integrity (necrosis score of 4) over the panniculus carnosus and adventitia were observed.
