Figure 1.

(A) Nucleotide sequence and the translation of open-reading-frame amino acids of the full length of a cDNA precursor from the skin secretion of Odorrana schmackeri. The putative peptide is double underlined, and the mature peptide is single underlined. The asterisk means stop codon, and the “Rana box” is highlighted by a red box. (B) Alignments of translated amino acid sequences of B1OS and brevinin family peptides derived from different frog species. The domains are divided into four parts, including the putative signal peptide (1), acidic spacer region (2), convertase processing site (-KR-) (3), and the mature brevinin peptide (4). The asterisks indicate conserved amino acid residues. The colon indicates strongly similar properties of conservation between groups. The period indicates weakly similar properties of conservation between groups.