Table 1.
Ferrets immunized with L-pampo protect against SARS-CoV-2 virus challenge.
| Immunization Group | Virus Replication | |||||
|---|---|---|---|---|---|---|
| 2 dpc | 4 dpc | 6 dpc | 8 dpc | 10 dpc | 12 dpc | |
| PBS | 4/4 1 | 4/4 | 4/4 | 4/4 | 3/4 | 1/4 |
| (16.8 ± 7.5) | (22.5 ± 2.8) | (21.7 ± 3.9) | (26.8 ± 3.3) | (24.4 ± 3.6) | (27.2 ± 0.0) | |
| Ag only | 6/6 1 | 6/6 | 6/6 | 5/6 | 2/6 | 0/6 |
| (21.1 ± 2.2) 2 | (25.8 ± 3.3) | (24.9 ± 4.5) | (29.6 ± 4.2) | (32.4 ± 3.5) | (0.0 ± 0.0) | |
| Ag + L-pampo | 6/6 | 5/6 | 3/6 | 0/6 | 0/6 | 0/6 |
| (31.2 ± 1.9) | (32.7 ± 1.3) | (31.2 ± 0.8) | (0.0 ± 0.0) | (0.0 ± 0.0) | (0.0 ± 0.0) | |
dpc: day post challenge. 1 Number of virus positive mouse/number of total mouse. 2 The mean ± SD of cycle threshold (Ct) the value in each group using qRT-PCR.