Table 4.
Determination of SLA-1 codons under positive selection by the Bayes empirical Bayes (BEB) approach.
Loci | Population | Model | dN/dS Value | Significance a | Codons Predicted to Be under Positive Selection BEB Inference b |
---|---|---|---|---|---|
SLA-1 (exon 2) | All | M7 vs. M8 | 3.36 | p < 0 | 6 **, 15 **, 53 **, 57 **, 58 **, 61 **, 64 **, 68 ** |
Exotic | M7 vs. M8 | 2.52 | p < 0.001 | 6 *, 15 *, 36 *, 53 **, 57 **, 58 **, 65 **, 68 ** | |
Local | M7 vs. M8 | 3.13 | p < 0 | 15 **, 36 **, 53 **, 56 **, 57 **, 58 **, 59 **, 61 *, 68 ** | |
Warthog | M7 vs. M8 | 4.55 | p < 0 | 15 **, 53 **, 58 *, 64 **, 65 ** | |
SLA-2 | All | M7 vs. M8 | 5.37 | p < 0 |
11 *, 17 **, 20 **, 28 **, 34 **, 35 **, 56 **, 64 **, 69 *, 77 **, 78 **, 79 *, 80 **, 81 *, 84 *, 88 **, 90 **, 91 *, 92 **, 106 **, 125 **, 127 **, 128 **, 154 **, 158 **, 162 **, 163 **, 166 **, 167 **, 174 **, 178 **, 180 **, 181 *, 286 *, 288 **, 312 **, 322 **, 345 *, 350 *, 351 ** |
Exotic | M7 vs. M8 | 5.52 | p < 0 |
17 **, 20 **, 34 *, 35 **, 56* *, 74 **, 78 **, 79 *, 80 **, 81 **, 84 **, 88 **, 90 **, 92 *, 106 **, 108 **, 125 **, 127 *, 158 **, 162 *, 163 **, 166 **, 167 **, 174 **, 178 **, 181 **, 312 *, 330 *, 350 *, 351 ** |
|
Local | M7 vs. M8 | 7.72 | p < 0 |
11 *, 17 **, 20 **, 28 **, 34 **, 35 **, 55 *, 56 **, 64 **, 73 **, 77 **, 78 **, 80 **, 88 **, 90 **, 91 **, 92 **, 106 *, 113 **, 125 **, 154 **, 158 **, 162 **, 163 **, 166 **, 167 **, 174 **, 178**, 180**, 288 *, 322 ** |
|
DQB1 | All | M7 vs. M8 | 11.72 | p < 0 | 8 *, 31 **, 35 **, 40**, 47 *, 48 **, 50 **, 52 *, 59 **, 60 **, 65 *, 79 **, 85 *, 88 **, 93 **, 99 *, 204 *, 242 ** |
Exotic | M7 vs. M8 | 12.28 | p < 0 | 8 **, 31 **, 35 **, 40 *, 47 **, 48 **, 49 *, 50 **, 52 **, 59 **, 60 *, 65 *, 79 **, 85 *, 88 **, 89 *, 93 *, 204 ** | |
Local | M7 vs. M8 | 10.39 | p < 0.00001 | 31 **, 35 **, 48 *, 52 *, 59 *, 60 *, 79 *, 88 *, 93 *, 113 *, 242 * |
a Significance was calculated by comparing the difference in the log likelihoods corresponding to the M7-M8 model. b Underlined are residues on the peptide-binding region (PBRs). * Posterior probability ≥ 0.95. ** Posterior probability ≥ 0.99.