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. 2021 Sep 14;13(9):1825. doi: 10.3390/v13091825

Figure 2.

Figure 2

Alignments of PEDV and SARS-CoV-2 3CLpro in protein sequence and crystal structure. (A) The sequences of the PEDV 3CLpro (Accession number: MN644470.1) and SARS-CoV-2 3CLpro (Accession number: YP_009725295.1) are aligned by Clustal Omega tool (https://www.ebi.ac.uk/Tools/msa/clustalo, accessed on 29 April 2021). The catalytic sites in SARS-CoV-2 3CLpro (His41 and Cys145) and PEDV (His41 and Cys144) are shown as red. (B) The crystal structures of PEDV 3CLpro (PDB: 4XFQ) and SARS-CoV-2 3CLpro (PDB: 6M2N) are aligned by PyMOL. PEDV 3CLpro is shown as pink cartoon, and SARS-CoV-2 3CLpro is shown as blue cartoon. The catalytic sites in SARS-CoV-2 3CLpro (His41 and Cys145) and PEDV (His41 and Cys144) are shown as red spheres.