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. 2021 Sep 9;13(9):1798. doi: 10.3390/v13091798

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of individual SARS-CoV-2 protein expression on cellular organization in transfected cells. Results are shown from Vero E6 cells transfected with epitope (Strep)-tagged E, M, S, Orf6, nsp3, nsp4, or N proteins (green). Golgi and ER architecture were monitored by labeling with anti-TGN46 (A) or anti-calnexin (B), respectively (red). Merged images are counterstained with DAPI (blue). Note the fragmentation of the Golgi apparatus by E, M, S, Orf6, or nsp3 expression. Note also changes in ER structure by all except the N protein. Bar = 10 μm.