Figure 2.

Role of VCP/p97 in the replication cycle of RNA-containing viruses. Since many RNA-containing viruses do not need the nucleus for their infectious cycles, this figure shows only a small portion of the cytoplasm, including an enlarged segment of the endoplasmic reticulum with a replication organelle (RO). Ribosomes are shown in blue, whereas viral RNAs are shown as red arrows. Viral nonstructural proteins are shown spanning the ER membrane in the RO. VCP is depicted as in Figure 1. Roles for VCP in flaviviral replication events have been documented for endosome fusion, RNA genome uncoating, and RO formation, although p97 participation in virion egress is not well documented. Other RNA-containing viruses have additional roles for p97 during viral replication. See text for details.