Table 4.

List of differentially expressed genes in brain tissue of terminally sick mice after RML and RML/LPS injection.

Gene	Gene Name	Fold Change	p-Value
DE genes in RML vs. saline
Sprn	Shadow of prion protein	−3.13	0.01
Lyz2	Lysozyme 2	4.08	0.001
Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	−6.20	0.01
Ncam1	Neural cell adhesion molecule 1	−3.90	0.02
Prkaca	Protein kinase, cAMP dependent, catalytic, alpha	−3.89	0.01
Egr1	Early growth response 1	−6.20	0.001
Tlr3	Toll-like receptor 3	2.56	0.03
Ache	Acetylcholinesterase	−3.90	0.08
Fcgr3	Fc receptor, IgG, low affinity III	2.59	0.09
Ly86	Lymphocyte antigen 86	4.08	0.06
Anp32a	Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	−1.95	0.08
Sod1	Superoxide dismutase 1, soluble	−3.12	0.06
Bax	Bcl2-associated X protein	−2.46	0.06
Prnp	Prion protein	−1.93	0.18
Prnd	Prion protein dublet	10.82	0.14
DE genes in RML + LPS vs. saline
Sprn	Shadow of prion protein	−1.94	0.01
C1qb	complement component 1, q subcomponent, beta polypeptide	2.61	0.03
Ly86	Lymphocyte antigen 86	2.05	0.02
Lyz2	Lysozyme 2	5.18	0.01
Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	−19.46	0.01
Anp32a	Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	−3.07	0.03
Ncam1	Neural cell adhesion molecule 1	−7.76	0.01
Sod1	Superoxide dismutase 1, soluble	−4.87	0.01
Prkaca	Protein kinase, cAMP dependent, catalytic, alpha	−3.84	0.03
Egr1	Early growth response 1	−4.85	0.001
H2-k1	Histocompatibility 2, K1, K region	2.58	0.02
C4b	Complement component 4B (Childo blood group)	6.51	0.09
Ifi27i2a	Interferon, alpha-inducible protein 27 like 2A	8.24	0.08
A2m	Alpha-2-macroglobulin	6.53	0.09
Prnp	Prion protein	−2.47	0.10
Prnd	Prion protein dublet	3.29	0.38