Table 3.
Probable sensory peripheral neuropathy + (n = 72) |
Probable sensory peripheral neuropathy − (n = 46) |
|
---|---|---|
Test + PRO-CTCAE Severity > 0/4 |
69 | 16 |
Test − PRO-CTCAE Severity = 0/4 |
3 | 30 |
Sensitivity = 95.83% | Specificity = 65.22% | |
Test + PRO-CTCAE Interference > 0/4 |
37 | 12 |
Test − PRO-CTCAE Interference = 0/4 |
35 | 34 |
Sensitivity = 51.39% | Specificity = 73.91% |
Painful CIPN + (n = 34) |
Painful CIPN − (n = 104) |
|
---|---|---|
Test + PRO-CTCAE Severity > 0/4 |
34 | 64 |
Test − PRO-CTCAE Severity = 0/4 |
0 | 40 |
Sensitivity = 100% | Specificity = 38.46% | |
Test + PRO-CTCAE Interference > 0/4 |
26 | 29 |
Test − PRO-CTCAE Interference = 0/4 |
8 | 75 |
Sensitivity = 76.47% | Specificity = 72.12% |
Table describes the sensitivity and specificity of the PRO-CTCAE Numbness and Tingling Severity and Interference Items to probable sensory peripheral neuropathy (n = 118) or painful CIPN (n = 138) at T3. Participants who reported Total Neuropathy Score-Clinical Version (TNSc©) Sensory scores ≥ 1/4 and either TNSc© Sensory Function: Vibration Sensibility scores ≥ 1/4 or TNSc© Reflexes scores ≥ 1/4 were classified as exhibiting probable sensory peripheral neuropathy [38]. Participants who reported TNSc© Sensory scores = 0/4 were classified as not exhibiting probable sensory peripheral neuropathy. Participants who reported 0–10 numerical rating scale of worst CIPN pain intensity scores ≥ 4/10 over the past week were interpreted as indicating the presence of painful CIPN [39]. Participants who reported < 4/10 worst CIPN pain intensity over the past week were classified as not experiencing painful CIPN. Higher scores on all measures represented worse symptom severity