Skip to main content
. 2021 Sep 27;13(9):1154–1166. doi: 10.4254/wjh.v13.i9.1154

Table 1.

Effects of probiotics on different disorders in experimental alcoholic liver disease

Disorder
Biomarker changes
Ref.
Liver steatosis ↓ Liver mass, ↓ content of triglycerides, free fatty acids, and cholesterol in the liver tissues [50-52,54]
Liver inflammation ↓ Myeloperoxidase activity, expression of tumor necrosis factor alpha gene and neutrophil infiltration in the liver [54]
Oxidative stress in liver ↓ Level of nitric oxide and malondialdehyde and ↑ level of glutathione and catalase in the liver tissue [50,51,54]
Death of hepatocytes ↓ Serum aminotransferases [50-54]
Systemic inflammation ↓ Serum IL-6 and tumor necrosis factor alpha [51-53]
Bacterial translocation ↓ Serum lipopolysaccharide [51-54]
Gut dysbiosis ↑ Firmicutes, Clostridiales and Lactobacillales; ↓ Proteobacteria and Campylobacterales [51,53]
Damage to the intestinal epithelium ↓ Serum diamine oxidase [53]
Increased intestinal permeability ↓ Serum D-lactate, ↑ the amount of occludin and other protein of tight junction in the gut epithelium, ↓ intestinal permeability for dyes [50,52-54]
Dyslipidemia ↓ Serum cholesterol and triglycerides [50,52-54]