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. 2021 Sep 27;13(9):979–1002. doi: 10.4254/wjh.v13.i9.979

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Overview of the main immune checkpoint and their respective targeted therapies. Made with biorender.com. APC: Antigen presenting cell; LT: T lymphocyte; MDSC: Myeloid derived suppressive cell; NK: Natural killer; Treg: Lymphocyte T regulator; LAG-3: Lymphocyte-activation gene 3; PD-L1: Program cell death ligand 1; TCR: T cell receptor.