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. 2021 Sep 27;13(9):979–1002. doi: 10.4254/wjh.v13.i9.979

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Overview of the main epigenetic mechanisms in hepatocellular carcinoma and their inhibitors. Made with biorender.com. A: DNA methylation; B: Histone modification. DNMT: DNA methyltransferase; TET: Ten-eleven translocation; DNMTis: DNA methyltransferase inhibitors; HAT: Histone acetyl transferase; HDAC: Histone deacetylase; HDACis: Histone deacetylase inhibitors; HMT: Histone methyl transferase; HDM: Histone demethylase; HMTis: Histone methyl transferase inhibitors; HCC: Hepatocellular carcinoma.