FIG. 5.

Schematic model for ILK-induced AP-1 activity. ILK regulates AP-1 activity through the GSK-3 pathway. Stimulation of ILK activity by adhesion of cells to FN results in an inhibition of GSK-3 activity, likely via direct phosphorylation of GSK-3. Inhibition of GSK-3 could prevent phosphorylation of the C terminus DNA-binding domain of c-jun, resulting in the formation of a protein-DNA complex and consequently an enhancement of AP-1 activity.