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. 2021 Sep 21;14:5911–5925. doi: 10.2147/IJGM.S329644

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© 2021 Gao et al.

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The identified features can distinguish sensitive cell lines from drug-resistant cell lines. (A) Comparison of SVM algorithms containing 1–9 characteristic genes. When more gene features are included, the accuracy and sensitivity of the SVM algorithm can be substituted, as with AUC. (B) Regardless of the subtype of lung cancer, the lnIC50 values of cell lines containing any mutations in the 9 genes were significantly higher, and these cell lines were resistant to cisplatin. (C) Considering the subtypes of lung cancer, with the exception of EMSO, cell lines containing mutations in the 9 genes had significantly higher lnIC50 values and were resistant to cisplatin. (D) Correlation analysis of cluster labels between SVMs and the k-means method. Cluster 0 by k-means was significantly enriched in more panel-WT cell lines. *, **, ***, ****, P<0.05, P<0.01, P<0.001, P<0.0001.

Abbreviation: ns, not significant.