Table 3.
Baseline Imaging Results Among Patients With Pulmonary or Central Nervous System Cryptococcosis
| Baseline Imaging Result | Total | Cryptococcus neoformans | Cryptococcus gattii | P Value |
|---|---|---|---|---|
| Chest imaging in pulmonary cryptococcosis | (n = 167) | (n = 77) | (n = 90) | |
| CT imaging | ||||
| Normal | 3 (1.8) | 2 (2.6) | 1 (1.1) | .60 |
| Single lobar infiltrate | 20 (12.0) | 9 (11.7) | 11 (12.2) | .92 |
| Multiple lobar infiltrate | 11 (6.6) | 10 (13.0) | 1 (1.1) | .0020 |
| Mass lesion | 95 (56.9) | 50 (64.9) | 45 (50.0) | .052 |
| Unilateral nodule | 64 (38.3) | 29 (37.7) | 35 (38.9) | .87 |
| Bilateral nodules | 38 (22.8) | 15 (19.5) | 23 (25.6) | .35 |
| Cavitation | 9 (5.4) | 4 (5.2) | 5 (5.6) | >.99 |
| Diffuse/interstitial | 7 (4.2) | 5 (6.5) | 2 (2.2) | .25 |
| Pleural effusion | 22 (13.2) | 11 (14.3) | 11 (12.2) | .69 |
| Brain imaging in CNS cryptococcosis | ||||
| CT imaging | (n = 325) | (n = 219) | (n = 106) | |
| Normal | 192 (59.1) | 152 (69.4) | 40 (37.7) | <.0001 |
| Hydrocephalus | 36 (11.1) | 17 (7.8) | 19 (17.9) | .0062 |
| Mass lesion | 32 (9.9) | 7 (3.2) | 25 (23.6) | <.0001 |
| MRI | (n = 127) | (n = 97) | (n = 30) | |
| Normal | 63 (49.6) | 56 (57.7) | 7 (23.3) | .0010 |
| Hydrocephalus | 10 (7.9) | 9 (9.3) | 1 (3.3) | .45 |
| Mass lesion | 23 (18.1) | 12 (12.4) | 11 (36.7) | .0025 |
Data are presented as No. (%) unless otherwise specified. χ 2 or Fisher exact test was used to compare categorical variables. Chest imaging data were available from all sites except Australia.
Abbreviations: CT, computed tomography; MRI, magnetic resonance imaging.