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. 2021 Sep 14;27(34):5753–5763. doi: 10.3748/wjg.v27.i34.5753

Table 1.

An overview of formulas and cutoffs for determining non-invasive marker panels for detection of liver fibrosis[10-12,21,22]

Formula
Equation
Lower cutoff
Higher cutoff
FIB-4 [Age (yr) × AST (IU/L)]/{platelet count (109/L) × [ALT(IU/L)]1/2} 1.3 2.67[11]
1.45 3.25[22]
APRI [(AST/ULN)/platelet count (109/L)] × 100 0.5 1.5[21]
NFS -1.675 + 0.037 × age (yr) + 0.094 × BMI (kg/m2) + 1.13 × IFG/diabetes (yes = 1, no = 0) + 0.99 × AST/ALT-0.013 × platelet count (× 109/L) - 0.66 × albumin (g/dL) -0.676 1.455[10]
BARD Scale 0-4; BMI ≥ 28 kg/m2 = 1 point; AST/ALT ≥ 0.8 = 2 points; Diabetes = 1 point 2[12]

ALT: Alanine aminotransferase; APRI: Aspartate aminotransferase to platelet ratio index; AST: Aspartate aminotransferase; BARD: Body mass index, aspartate aminotransferase/alanine aminotransferase ratio, diabetes score; BMI: Body mass index; FIB-4: Fibrosis-4 index; IFG: Impaired fasting glucose; NFS: Nonalcoholic fatty liver disease fibrosis score; ULN: Upper limit of normal.