Table 2.
Baseline characteristics of the patients
|
|
Overall, n = 417
|
No/mild fibrosis, n = 261
|
Advanced fibrosis, n = 156
|
P
value
|
| Age (yr) | 40.54 ± 10.95 | 39.42 ± 11.39 | 42.41 ± 9.94 | 0.007 |
| Male, n (%) | 354 (84.9) | 219 (83.9) | 135 (86.5) | 0.468 |
| BMI (kg/m2) | 25.48 ± 2.66 | 25.51 ± 2.56 | 25.42 ± 2.83 | 0.757 |
| Diabetes mellitus, n (%) | 82 (19.7) | 46 (17.6) | 36 (23.1) | 0.175 |
| Hypertension, n (%) | 42 (10.1) | 30 (11.5) | 12 (7.7) | 0.212 |
| ALB (g/L) | 42.53 ± 4.96 | 43.65 ± 5.14 | 40.65 ± 3.98 | < 0.001 |
| GLO (g/L) | 29.88 ± 14.11 | 29.11 ± 6.00 | 31.13 ± 21.53 | 0.160 |
| ALT (U/L) | 133.07 ± 199.05 | 126.93 ± 151.37 | 143.33 ± 260.27 | 0.416 |
| AST (U/L) | 70.69 ± 85.14 | 63.24 ± 62.19 | 83.17 ± 112.77 | 0.021 |
| GGT (U/L) | 89.64 ± 109.58 | 88.75 ± 117.46 | 91.11 ± 95.28 | 0.832 |
| FPG (mmol/L) | 5.34 ± 1.42 | 5.28 ± 1.20 | 5.45 ± 1.73 | 0.251 |
| Cr (μmol/L) | 73.41 ± 13.71 | 74.00 ± 13.50 | 72.41 ± 14.07 | 0.273 |
| UA (μmol/L) | 368.49 ± 82.08 | 377.02 ± 83.87 | 353.77 ± 76.98 | 0.007 |
| TG (mmol/L) | 1.67 ± 1.12 | 1.78 ± 1.45 | 1.48 ± 0.71 | 0.016 |
| HDL-C (mmol/L) | 1.12 ± 0.30 | 1.12 ± 0.29 | 1.12 ± 0.33 | 0.959 |
| PLT (× 109/L) | 204.00 ± 64.22 | 221.00 ± 62.76 | 175.52 ± 56.22 | < 0.001 |
| FIB-4 | 1.48 ± 1.64 | 1.19 ± 1.65 | 1.97 ± 1.49 | < 0.001 |
| APRI | 1.03 ± 1.72 | 0.84 ± 1.33 | 1.34 ± 2.19 | 0.003 |
| NFS | -2.16 ± 1.38 | -2.56 ± 1.24 | -1.50 ± 1.33 | < 0.001 |
| BARD (%) | < 0.001 | |||
| 0 | 209 (50.1) | 145 (55.6) | 64 (41.0) | |
| 1 | 86 (20.6) | 59 (22.6) | 27 (17.3) | |
| 2 | 92 (22.1) | 48 (18.4) | 44 (28.2) | |
| 3 | 25 (6.0) | 8 (3.1) | 17 (10.9 ) | |
| 4 | 5 (1.2) | 1 (0.4) | 4 (2.6) |
ALB: Albumin; ALT: Alanine aminotransferase; APRI: Aspartate aminotransferase to platelet ratio index; AST: Aspartate aminotransferase; BARD: Body mass index, aspartate aminotransferase/alanine aminotransferase ratio, diabetes score; BMI: Body mass index; Cr: Creatinine; FIB-4: Fibrosis-4 index; FPG: Fasting plasma glucose; GGT: γ-Glutamyl transpeptidase; GLO: Globulin; HDL-C: High-density lipoprotein cholesterol; NFS: Non-alcoholic fatty liver disease fibrosis score; PLT: Platelet; TG: Triglyceride; UA: Uric acid.