Table 1.
Potential benefits of the different modalities of machine perfusion of the liver on clinical studies
|
|
Safety and feasibility
|
Prevention of early allograft dysfunction
|
Prevention of biliary complications
|
Prolonged preservation time
|
Viability assessment
|
Therapeutic interventions
|
| Normothermic regional perfusion1 | Yes[11,19,46] | Yes[11,19,46] | Yes[11,19,46] | No data available yet | Yes[11,46] | No data available yet |
| Normothermic machine perfusion | Yes[2,6,21,42,50,51] | Yes[2,6,42] | No data available yet | Yes[2,6] | Yes[6,24,26,50,51] | Yes[43]2 |
| Subnormothermic machine perfusion | No data available yet | No data available yet | No data available yet | No data available yet | No data available yet | No data available yet |
| Hypothermic machine perfusion | Yes[3,37] | Yes[3,37] | Yes[3,22,37] | Yes[39]2 | Yes[34] | No data available yet |
| Controlled oxygenated rewarming | Yes[9,47] | Yes[9,47] | No data available yet | No data available yet | No data available yet | No data available yet |
| Combined modalities (HMP + NMP) | Yes[14,15] | No data available yet | No data available yet | Yes[39]2 | Yes[14,15] | No data available yet |
| Ischaemia-free liver transplantation3 | Yes[12,48] | Yes[48,49] | No data available yet | No data available yet | No data available yet | No data available yet |
1
Only suitable for donors after circulatory death.
2
Only pre-clinical studies available so far.
3
Only suitable for donors after brain death. HMP: Hypothermic machine perfusion; NMP: Normothermic machine perfusion.