Table 3.
Clinical characteristics of colorectal cancer patients and MTNR1B genotypes (rs10830963 and rs1447352)
| Variables | Total |
rs10830963 (C>G)
|
rs1447352 (A>G)
|
||||||||||
|
CC (%)
|
CG (%)
|
GG (%)
|
P
value
|
CC + CG (%)
|
P
value
|
GG (%)
|
GA (%)
|
AA (%)
|
P
value
|
GG + GA (%)
|
P
value
|
||
| Sex | |||||||||||||
| Male | 39 (41.5) | 7 (33.3) | 22 (44.9) | 10 (43.5) | 0.66 | 29 (41.4) | 1.00 | 4 (66.7) | 16 (43.2) | 19 (38.0) | 0.40 | 20 (46.5) | 0.53 |
| Female | 55 (58.5) | 14 (66.7) | 27 (55.1) | 13 (56.5) | 41 (58.6) | 2 (33.3) | 21 (56.8) | 31 (62.0) | 23 (53.5) | ||||
| Age at surgery | |||||||||||||
| mean ± SD (yr) | 64.2 ± 13.8 | 67.0 ± 14.0 | 61.4 ± 13.9 | 66.8 ± 13.1 | 0.16 | 63.1 ± 14.0 | 0.26 | 69.7 ± 14.1 | 64.4 ± 14.0 | 63.0 ± 13.8 | 0.53 | 65.1 ± 14.0 | 0.47 |
| < 65 | 50 (53.2) | 11 (52.4) | 28 (57.1) | 11 (47.8) | 0.75 | 39 (55.7) | 0.63 | 3 (50.0) | 18 (48.6) | 29 (58.0) | 0.68 | 21 (48.8) | 0.41 |
| ≥ 65 | 44 (46.8) | 10 (47.6) | 21 (42.9) | 12 (52.2) | 31 (44.3) | 3 (50.0) | 19 (51.4) | 21 (42.0) | 22 (51.2) | ||||
| Stage | |||||||||||||
| I | 12 (12.8) | 2 (9.5) | 6 (12.2) | 4 (17.4) | 0.56 | 8 (11.4) | 0.30 | 0 (0) | 4 (10.8) | 8 (16.0) | 0.54 | 4 (9.3) | 0.60 |
| II | 34 (36.2) | 8 (38.1) | 18 (36.7) | 7 (30.4) | 26 (37.1) | 1 (16.7) | 15 (40.5) | 17 (34.0) | 16 (37.2) | ||||
| III | 30 (31.9) | 9 (42.9) | 16 (32.7) | 5 (21.7) | 25 (35.7) | 4 (66.7) | 12 (32.4) | 14 (28.0) | 16 (37.2) | ||||
| IV | 18 (19.1) | 2 (9.5) | 9 (18.4) | 7 (30.4) | 11 (15.7) | 1 (16.7) | 6 (16.2) | 11 (22.0) | 7 (16.3) | ||||
| Adjuvant chemotherapya | |||||||||||||
| No | 23 (24.5) | 5 (23.8) | 12 (25.5) | 6 (30.0) | 0.90 | 17 (25.0) | 0.77 | 1 (16.7) | 8 (22.2) | 14 (30.4) | 0.61 | 9 (21.4) | 0.47 |
| Yes | 65 (69.1) | 16 (76.2) | 35 (74.5) | 14 (70.0) | 51 (75.0) | 5 (83.3) | 28 (77.8) | 32 (69.6) | 33 (78.6) | ||||
| Tumor locationa | |||||||||||||
| Colon | 74 (78.7) | 20 (95.2) | 41 (87.2) | 13 (65.0) | 0.02 | 61 (89.7) | 0.01 | 6 (100) | 34 (94.4) | 34 (73.9) | 0.02 | 40 (95.2) | < 0.001 |
| Rectum | 14 (14.9) | 1 (4.85) | 6 (12.8) | 7 (35.0) | 7 (10.3) | 0 (0) | 2 (5.6) | 12 (26.1) | 2 (4.8) | ||||
| CDKN2A gene | |||||||||||||
| Unmethylation | 43 (45.7) | 12 (57.1) | 17 (34.7) | 13 (56.5) | 0.10 | 29 (41.4) | 0.31 | 4 (66.7) | 16 (43.2) | 22 (44.0) | 0.55 | 20 (46.5) | 0.97 |
| Methylation | 51 (54.3) | 9 (42.9) | 32 (65.3) | 10 (43.5) | 41 (58.6) | 2 (33.3) | 21 (56.8) | 28 (56.0) | 23 (53.5) | ||||
| MLH1 gene | |||||||||||||
| Unmethylation | 77 (81.9) | 18 (85.7) | 39 (79.6) | 19 (82.6) | 0.83 | 57 (81.4) | 1.00 | 5 (83.3) | 31 (83.8) | 40 (80.0) | 0.90 | 36 (83.7) | 0.79 |
| Methylation | 17 (18.1) | 3 (14.3) | 10 (20.4) | 4 (17.4) | 13 (18.6) | 1 (16.7) | 6 (16.2) | 10 (20.0) | 7 (16.3) | ||||
| MGMT gene | |||||||||||||
| Unmethylation | 46 (48.9) | 8 (38.1) | 26 (53.1) | 12 (52.2) | 0.50 | 34 (48.6) | 0.95 | 4 (66.7) | 18 (48.6) | 24 (48.0) | 0.68 | 22 (51.2) | 0.92 |
| Methylation | 48 (51.1) | 13 (61.9) | 23 (46.9) | 11 (47.8) | 36 (51.4) | 2 (33.3) | 19 (51.4) | 26 (52.0) | 21 (48.8) | ||||
| Death in 5 yr | |||||||||||||
| No | 76 (80.9) | 19 (90.5) | 43 (87.8) | 13 (56.5) | < 0.001 | 62 (88.6) | < 0.001 | 6 (100) | 33 (89.2) | 36 (72.0) | 0.06 | 39 (90.7) | 0.03 |
| Yes | 18 (19.1) | 2 (9.5) | 6 (12.2) | 10 (43.5) | 8 (11.4) | 0 (0) | 4 (10.8) | 14 (28.0) | 4 (9.3) | ||||
a
The total number of patients with colorectal cancer does not correspond because of missing data. CRC: Colorectal cancer.