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. 2021 Sep 13;8:726943. doi: 10.3389/fcvm.2021.726943

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Copyright © 2021 Sharma, Zhao, Mentkowski, Sonkawade, Karthikeyan, Lang and Ying.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative images from the mouse model of acute myocardial infarction (MI). (A) TTC stained mouse heart sections at 1 mm after myocardial infraction. The viable myocardium appeared in blue and the area at risk (AAR) in bright red. (B) Histological demonstration of a thinned myocardium (shown by an arrow) in a mouse that underwent left anterior descending artery ligation. (C) Comparative histology from a normal control mouse. (D) Contrast-enhanced cardiac MRI showing anterior wall scar and wall thinning in a mouse model. (E) Cardiac MRI showing normal left ventricular morphology.