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. 2021 Sep 26;11(9):e525. doi: 10.1002/ctm2.525

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© 2021 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The cellular m⁶A machinery. m⁶A modification is a dynamic, reversible, and multilayered process. The writer complex has been identified as METTL3, METTL14, WATP, RBM15/15B, KIAA1429, and ZC3H13, which adds m⁶A methylation on target RNAs. The two erasers, FTO and ALKBH5, remove the m⁶A methylation from target RNAs. m⁶A is recognized by diverse readers, mainly HNRNPC, HNRNPG, HNRNBPA2B1, YTHDC1/2, and YTHDF1/2/3, which mediate various posttranscriptional processes including mRNA export, splicing, stabilization, decay, and translation, in addition to miRNA processing.