TABLE 1.
The relationship between m6A regulators and various CSCs
| Cancer types | M6A regulators | Molecular axis | Function | Model system | Reference |
|---|---|---|---|---|---|
| GBM | METTL3 | METTL3/SOX2 | Promoting stemness of GSCs | In vivo | 71 |
| METTL14 | METTL3/METTL14/ADAM19 | Inhibiting stemness of GSCs | In vitro and in vivo | 12 | |
| ALKBH5 | ALKBH5/FOXM1 | Promoting stemness of GSCs | In vitro and in vivo | 11 | |
| FTO | Promoting stemness of GSCs | In vivo | 12 | ||
| IGF2BP2 | IGF2BP2/Let‐7family | Promoting stemness of GSCs | In vitro and in vivo | 73 | |
| HMGA1 | Promoting stemness of GSCs | In vivo | 74 | ||
| YTHDF2 | YTHDF2/MYC/IGFBP2 | Promoting stemness of GSCs | In vitro and in vivo | 75 | |
| PC | HNRNPA2B1 | HNRNPA2B1/UCA1/KRAS | Promoting stemness of pancreatic CSCs | In vitro | 76 |
| IGF2BP2 | IGF2BP2/DANCR | Promoting stemness of pancreatic CSCs | In vitro and in vivo | 77 | |
| CRC | METTL3 | METTL3/SOX2 | Promoting stemness of colorectal CSCs | In vitro and in vivo | 78 |
| YTHDF1 | YTHDF1/FZD9/WNT6/Wnt//β‐cantenin pathway | Promoting stemness of colorectal CSCs | In vitro and in vivo | 79 | |
| HCC | YTHDF2 | YTHDF2/OCT4 | Promoting stemness of liver CSCs | In vitro and in vivo | 80 |
| IGF2BP2 | IGF2BP2/ROS production | 81 | |||
| BC | ALKBH5 | ALKBH5/NANOG | Promoting stemness of BCSCs | In vitro and in vivo | 10 |
| OC | FTO | FTO/PDEC1/PDE4B/cAMP pathway | Inhibiting stemness of OCSCs | In vitro and in vivo | 85 |
| EC | ALKBH5 | ALKBH5/SOX2 | Promoting stemness of ECSCs | In vitro and in vivo | 25 |
| AML | METTL14 | SPI1/METTL14/MYB/MYC | Promoting stemness of LSCs | In vitro and in vivo | 68 |
| ALKBH5 | ALKBH5/TACC3 | Promoting stemness of LSCs | In vitro and in vivo | 88 | |
| FTO | Promoting stemness of LSCs | In vitro and in vivo | 89, 90 | ||
| IGF2BP1 | IGF2BP1/ALDH1A1/HOXB4/MYB | Promoting stemness of LSCs | In vitro and in vivo | 91 | |
| YTHDF2 | Promoting stemness of LSCs | In vitro and in vivo | 92 | ||
| OS | METTL3 | Pluripotency of stem cells/Wnt pathway | Promoting stemness of OSCs | In vitro | 94 |
| BCa | METTL3 | METTL3/AFF4/SOX2/MYC | Promoting stemness of BCa stem cells | In vitro | 95 |
| cSCC | METTL3 | METTL3/ΔNp6 | Promoting stemness of cSCC stem cells | In vitro | 96 |
m6A, N6‐methyladenosine; GBM, glioblastoma; PC, pancreatic cancer; CRC, colorectal cancer; HCC, hepatocellular carcinoma; BC, breast cancer; OC, ovarian cancer; EC, endometrial cancer; AML, acute myeloid leukemia; OS, osteosarcoma; BCa, bladder cancer; cSCC, cutaneous squamous cell carcinoma; GSCs, glioblastoma stem cells; CSCs, caner stem cells; BCSCs, breast cancer stem cells; OCSCs, ovarian cancer stem cells; ECSCs, endometrial cancer stem cells; LSCs, leukemia stem cells; OSCs, osteosarcoma cancer stem cells.