Table 1.

Clinical outcomes and patient costs* for the clinical and economic review

Clinical outcomes for clinical review
Outcome category		Outcome indicator
		Sought	Identified
Earlier diagnosis	Disease severity at diagnosis - microbiology	smear positivity among bacteriologically-confirmed TB patients; smear grade; Xpert cycle threshold values; culture grade/colonies; time to culture positivity	smear positivity among bacteriologically-confirmed TB patients; smear grade
	Disease severity at diagnosis - radiology	CXR severity score/grading	-
	Disease severity at diagnosis - anthropometric	body mass index	-
Earlier diagnosis and linkage to care	Time to first contact with health services	duration from start of symptoms to first contact with health services	duration from start of symptoms to first contact with health services
	Time to diagnosis	duration from start of symptoms to diagnosis	duration from start of symptoms to diagnosis
	Time to treatment start	duration from start of symptoms to treatment start; time between diagnosis and treatment start	duration from start of symptoms to treatment start; time between diagnosis and treatment start
	Pre-treatment loss to follow-up	lost to follow-up between diagnosis and treatment start	lost to follow-up between diagnosis and treatment start
Treatment	Treatment outcomes at treatment end	treatment success (cure and completion); lost to follow-up	treatment success (cure and completion); lost to follow-up
	Disease outcome at treatment end - morbidity	body mass index; lung function test results; TB recurrence	-
Deaths	Mortality among screened and unscreened groups	all-cause mortality; TB-specific mortality	all-cause mortality
	Case fatality among diagnosed TB patients	all-cause case fatality; TB-specific case fatality	-
	Case fatality among treated TB patients	all-cause case fatality; TB-specific case fatality	all-cause case fatality; TB-specific case fatality
Patient costs* for economic review
Outcome category		Outcome - cost input
Pre-diagnosis	Costs before TB diagnosis	Direct medical - consultation/administration fees; drugs (TB, other); hospitalisation; laboratory investigations, radiology investigations, other investigations Direct non-medical costs - transport, food, accommodation, nutritional supplements, childcare Indirect - productivity loss
Diagnosis	Costs during TB diagnosis
Pre-treatment	Costs before TB treatment May include pre-diagnosis and diagnosis costs
Treatment	Costs during TB treatment
Entire illness period	Costs during the illness period reported in the study
Catastrophic cost	Prevalence	proportion of total cost for TB care >20% of annual household income

*costs incurred by TB patients and their households