Table 3.

Virulence factors among classical and hypervirulent Klebsiella pneumoniae and their function.

Virulence factor	Function	Location in the genome	Classical K. pneumoniae	Hypervirulent K. pneumoniae
allABCDRS, ybbW, ybbY, fdrA, fyuA, gcl, hyi, KP1_1364, KP1_1371, ylbE, ylbF	Allantoinase cluster for Allantoin metabolism	Chromosome	X	√
arc	Arginine deiminase	Chromosome	X	√
clbABCDEFGHIJKLMNOPQR	Colibactin gene cluster	Chromosome	X	√
iroBCDN	Salmochelin	Virulence plasmid	X	√
Irp1, irp2	Yersiniabactin receptors	Chromosome	√	√
iutA, iucABCD	Aerobactin synthesis	Virulence plasmid	X	√
kfuABC	Iron uptake cluster	Chromosome	√/X	√
glxK, glxR	Glycerate pathway	Chromosome	X	√
kvgA, kvgS	Two-component regulator system regulating capsule synthesis	Chromosome	X	√
mceABCDEGHIJ	Microcin E492	Chromosome	X	√
mrkABCDFHIJ	Type 3 fimbriae	Chromosome	√	√
rmpA, rmpA2	Regulators of mucoid phenotype	Virulence plasmid	X	√
ybtAEPQSTUX	Yersiniabactin synthesis	Chromosome	√	√

X, absent; √, present; √/X, present/absent.