Table 6.
Adjusted§ association between maternal PCB concentrations (lipid adj.) to thyroid function of mothers and newborns in the EHF-Assaf-Harofeh-Ichilov birth cohort, Israel, 2013–2015, grouped by maternal pre-pregnancy BMI (n = 157).
| PCB 118 (95% CI) | PCB 138 (95% CI) | PCB 153 (95% CI) | PCB 180 (95% CI) | Sum PCBs (95% CI) | |
|---|---|---|---|---|---|
| % Change in thyroid function parameter according to 1% change in exposure | |||||
| Maternal TSH | |||||
| BMI <19 | 0.47 (0.06; 0.88)# | 0.59 (0.18; 0.99)# | 0.51 (0.15; 0.87)# | 0.44 (0.1; 0.79)# | 0.57 (0.18; 0.96)# |
| BMI 19–25 | 0.04 (0.28; −0.20) | −0.05 (0.23; −0.32) | −0.09 (0.16; −0.34) | −0.12 (0.14; −0.37) | −0.067 (0.21; −0.35) |
| BMI ≥ 25 | −0.18 (0.12; −0.48) | −0.13 (0.14; −0.41) | −0.15 (0.12; −0.42) | −0.17 (0.10; −0.45) | −0.16 (0.13; −0.45) |
| Maternal FT4 | |||||
| BMI <19 | 0.11 (−0.02; 0.25) | 0.09 (−0.04; 0.23) | 0.08 (−0.04; 0.20) | 0.08 (−0.03; 0.20) | 0.1 (−0.03; 0.22) |
| BMI 19–25 | (0.11; −0.08) | −0.04 (−0.14; 0.06) | 0.01 (−0.09; 0.09) | 0.04 (−0.03; 0.12) | 0.01 (0.08; −0.07) |
| BMI ≥ 25 | 0.08 (0.19; −0.04) | 0.01 (−0.09; 0.11) | 0.03 (−0.07; 0.13) | 0.05 (−0.03; 0.13) | 0.04 (0.13; −0.05) |
| Maternal TG Ab | |||||
| BMI <19 | 0.37 (−0.22; 0.96) | 0.17 (−0.41; 0.76) | 0.12 (−0.40; 0.63) | 0.08 (−0.42; 0.58) | 0.15 (−0.41; 0.71) |
| BMI 19–25 | −0.07 (−0.40; 0.27) | −0.03 (−0.41; 0.36) | 0.08 (−0.29; 0.45) | 0.20 (−0.18; 0.58) | 0.07 (−0.32; 0.46) |
| BMI ≥ 25 | 0.13 (−0.30; 0.55) | 0.14 (−0.27; 0.54) | 0.08 (−0.30; 0.47) | 0.12 (−0.28; 0.54) | 0.12 (−0.31; 0.55) |
| Maternal TPO Ab | |||||
| BMI <19 | 0.53 (0.04; 1.03)# | 0.48 (−0.02; 0.98) | 0.46 (0.02; 0.90)# | 0.32 (−0.11; 0.76) | 0.48 (−0.004; 0.96) |
| BMI 19–25 | −0.12 (−0.41; 0.17) | −0.08 (−0.41; 0.25) | −0.08 (−0.39; 0.23) | −0.03 (−0.37; 0.31) | −0.09 (−0.42; 0.25) |
| BMI ≥ 25 | 0.17 (−0.19; 0.54) | 0.23 (−0.12; 0.57) | 0.20 (−0.14; 0.53) | 0.09 (−0.26; 0.44) | 0.19 (−0.17; 0.56) |
| Newborn total T4 | |||||
| BMI <19 | 0.02 (−0.19; 0.22) | −0.09 (−0.30; 0.12) | −0.10 (−0.10; 0.081) | −0.13 (−0.30; 0.052) | −0.10 (−0.30; 0.095) |
| BMI 19–25 | −0.03 (0.07; −0. 14) | 0.01 (0.15; −0.13) | 0.01 (0.13; −0.12) | −0.02 (0.12; −0.16) | 0 (0.13; −0.13) |
| BMI ≥ 25 | −0.03 (0.11; −0.17) | −0.03 (0.12; −0.18) | −0.02 (0.10; −0.15) | −0.05 (0.10; −0.20) | −0.03 (0.11; −0.18) |
§
Mother age, newborn gender, PCBs levels, interaction between gender and PCB levels and interaction between BMI categories and PCB levels were included the model of linear regression.
#
P < 0.05.
TSH, Thyroid-stimulating hormone; FT4, Free Thyroxine; Tg Ab, Thyroglobulin autoantibodies; TPO Ab, Thyroid peroxidase antibodies; NB T4, newborn total thyroxine; PCB, polychlorinated biphenyl.
Bold: p-value < 0.05.