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. 2021 Sep 13;12:704647. doi: 10.3389/fendo.2021.704647

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Copyright © 2021 Proia, Amato, Drid, Korovljev, Vasto and Baldassano

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential key factors of bone homeostasis and remodeling: the bone is modulated by nutrition and by physical activity. Nutrition influences the release of hormones like gut peptides (GLP-1, GLP-2, and GIP) and modulates the secretion of parathyroid hormone (PTH). Both in turn influence bone remodeling. Physical activity, adequate in volume and intensity, could impact bone homeostasis by influencing hormones released by peripheral organs. This figure is our own creation.