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After activation of innate immune cells, especially myeloid dendritic cells, large amounts of interleukin-12 (IL-12) were secreted. IL-33 and IL-12 had a synergistic effect in stimulating NK cells, NKT cells, ILC1, and Th1 to secrete more IFN-γ, which will aggravate tissue damage. NK cells, natural killer cells; NKT cell, natural killer T cell; ILC, innate lymphoid cell.
