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Interleukin-33 (IL-33) could promote tissue repair and fibrosis. IL-33 could promote the proliferation of Treg to further alleviate inflammation. IL-33 could also promote extracellular matrix deposition and tissue fibrosis by acting on mast cells, eosinophil, M2 macrophage, ILC2 cells, and Treg to increase the secretion of IL-5, IL-13, and other cytokines. ILC, innate lymphoid cell; Treg, regulatory T cell.
