Figure 4.

Correlation of KLF4 gene expression levels in peripheral blood with SOFA score, SOFA subscores and serum levels of IL-10 in patients with community-acquired pneumonia at admission to hospital. Horowitz index (oxygenation index, PaO₂/FiO₂), Glasgow Coma Scale, mean arterial pressure, total bilirubin, thrombocyte count, serum creatinine, IL-10 serum levels and KLF4 gene expression levels in peripheral blood were determined in 371 patients with community-acquired pneumonia (CAP) at presentation to hospital (A). KLF4 gene expression levels (in copies per cell, vertical axis) were correlated with the SOFA score (in points) (B), the IL-10 serum concentration (in pg/ml, values natural log-transformed) (C) and the SOFA subscores: Horowitz index (in kPa, original values divided by 100) (D), Glasgow Coma Scale (in points, values split into the categories 15 points or below 15 points) (E), mean arterial pressure (in kPa) (F), serum bilirubin (in µmol/l, values natural log-transformed) (G), thrombocyte count (in millions/µl) (H), and serum creatinine (in µmol/l, values natural log-transformed) (I). Green dots represent patients with positive testing for S. pneumoniae (blood culture, culture of respiratory material, or urinary antigen testing), red dots represent patients with negative testing for S. pneumoniae, and grey dots represent patients without testing for S. pneumoniae (N.A.). Graphs show scatter plots with trendline (B–D, F–I), or boxplots with interquartile range (E). Data points overlaying the boxplots are scattered horizontally. FiO₂, fraction of oxygen in the inhaled air (in percent); PaO₂, oxygen partial pressure in capillary or arterial blood (in mmHg).