Table 3.
Univariate and Multivariable Logistic Regression Analyses for the Risk of Coexisting Autoimmune Diseases in Patients with Alopecia Areata
| Variables | OR (95% CI) | P-value | Adjusted OR (95% CI) | P-value |
|---|---|---|---|---|
| Female | 2.20 (1.14–4.23) | 0.018* | 2.45 (1.24–4.82) | 0.011* |
| Age at AA onset | ||||
| ● < 18 | Reference | |||
| ● 18–30 | 1.22 (0.28–1.86) | 0.497 | ||
| ● 31–45 | 1.45 (0.22–1.91) | 0.199 | ||
| ● 46–60 | 1.64 (0.23–2.62) | 0.514 | ||
| ● > 60 | 1.72 (0.21–3.45) | 0.603 | ||
| Duration of disease > 1 year | 1.60 (1.20–4.49) | 0.041* | 1.13 (0.69–2.01) | 0.072 |
| AA subtype | ||||
| ● Patch-type AA | Reference | |||
| ● Multiple AA | 1.24 (0.29–2.52) | 0.072 | ||
| ● AT/AU | 0.62 (0.39–2.15) | 0.845 | ||
| ● Ophiasis | 0.89 (0.06–1.42) | 0.999 | ||
| Severity of AA (SALT score) | ||||
| ● 0–25% | Reference | |||
| ● 26–50% | 1.41 (0.82–3.59) | 0.153 | ||
| ● 51–75% | 0.94 (0.11–6.67) | 0.870 | ||
| ● 76–100% | 1.69 (0.21–2.33) | 0.555 | ||
| Body hair involvement | 2.91 (1.03–8.28) | 0.043* | 2.71 (0.90–8.16) | 0.076 |
| Nail abnormalities | 2.38 (1.13–5.05) | 0.021* | 2.49 (1.14–5.46) | 0.023* |
| Atopic diseases | 1.84 (1.12–2.51) | <0.001* | 1.98 (1.09–2.43) | <0.001* |
| Family history of AA | 0.76 (0.07–5.06) | 0.633 | ||
| Family history of AD | 1.15 (0.21–2.68) | 0.468 |
Note: *Statistically significant.
Abbreviations: AA, alopecia areata; AD, autoimmune disease; AT/AU, alopecia totalis/alopecia universalis; CI, confidence interval; OR, odds ratio; SALT, Severity of Alopecia Tool.