Table 1.

Pharmacokinetic Parameters of HH-N25 After an iv Injection (3 mg/kg Body Weight) in Male Sprague Dawley Rats

	HH-N25 (3.0 mg/kg, iv)
AUC (ng/mL/h)	2415.63 ± 256.51
Tmax (h)	0.14 ± 0.06
Cmax (ng/mL)	1446.67 ± 312.05
T1/2 (h)	4.51 ± 0.27
CL/f (mL/h/kg)	8.32 ± 1.45
VD/f (mL/kg)	1.26 ± 0.15
MRT (h)	2.56 ± 0.16

Note: Data are expressed as mean ± SEM (n=3 per group).

Abbreviations: C_max, maximum observed concentration; AUC, area under the concentration-time curve; T_1/2, elimination half-life; MRT, mean residence time; CL/f, mean oral clearance; VD/f, apparent volume of distribution; f, fraction absorbed (bioavailability).