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. 2021 Sep 21;4(11):e202101081. doi: 10.26508/lsa.202101081

Figure 2. Oxygen consumption rate (OCR) and ECAR metabolic profiles of ex vivo overnight-rested or activated CD8+ T cells from HIV-chronic cART–naïve and chronic CART–treated donors.

Figure 2.

(A) illustrates a representative OCR profile of overnight-rested CD8+ T cells from HIV-uninfected (black line), HIV-chronic cART–naïve (blue line), and HIV-chronic cART–treated (purple line) donors. (B, C, D) Hollow bars represent baseline, ATP-linked, and spare capacity OCRs of overnight-rested CD8+ T cells from HIV-uninfected (black line, n = 5), HIV-chronic cART–naïve (blue line, n = 7), and HIV-chronic cART–treated (purple line, n = 6) donors. (E) illustrates a representative ECAR profile of overnight-rested CD8+ T cells from HIV-uninfected (black line), HIV-chronic cART–naïve (blue line), and HIV-chronic cART–treated (purple line) donors. (F, G, H) Hollow bars represent baseline, maximal, and glycolytic capacity ECARs of overnight-rested CD8+ T cells from HIV-uninfected (black line, n = 5), HIV-chronic CART–naïve (blue line, n = 7), and HIV-chronic cART–treated (purple line, n = 6) donors. Data are representative of at least three technical repeats. * indicates P < 0.05, **P < 0.01, and ***P < 0.001 by unpaired two-tailed nonparametric Mann–Whitney test. Error bars are mean ± SEM.