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. 2021 Sep 20;4(11):e202000703. doi: 10.26508/lsa.202000703

Figure 5. Choroid plexus hAPP(SwInd) expression impairs hippocampal LTP.

Figure 5.

(A) Schematic of mutant APP ChPl model involving a single icv injection of AAV5 expressing human mutated APP(SwInd) or eGFP (control) in wild type mice. (B) Comparison of stimulus-response (input/output) relationship in CA1 region between AAV5-hAPP(SwInd) (N = 5, n = 13, black squares) and AAV5-eGFP (N = 7, n = 10, red dots) injected mice. (C) Comparison of paired pulse facilitation between AAV5-hAPP(SwInd) (N = 6, n = 13) and AAV5-eGFP (N = 8, n = 13) injected mice. (D) LTP was induced by high frequency stimulation (HFS) at Schaffer collateral-CA1 synapses after 20 min baseline recording of slices from mice injected with AAV5-hAPP(SwInd) (N = 4, n = 9) or AAV5-eGFP (N = 5, n = 7). Representative traces showing responses before (dashed line) and 60 min after tetanus delivery (bold line). *P < 0.05; ANOVA; all values: mean ± SEM; N, number of animals; n, number of slices; icv, intracerebroventricular. Calibration bars: 10 ms, 0.2 mV.