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. 2021 Sep 22;14(12):101228. doi: 10.1016/j.tranon.2021.101228

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© 2021 The Authors. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 3 — Mammary ductal development in control, MTB-IGFIR, MTB-200ba429 and MTB-IGFIRba429 mice. (A,C,D,G) Wholemount analysis and (B,D,F,H) histologic analysis of 55-day old mammary glands from (A,B) MTB-IGFIR, (C,D) MTB-IGFIRba429, (E,F) control, and (G,H) MTB-200ba429 mice. Insets show a magnified version of the terminal end buds. White arrows indicate hyperplastic lesions while LN indicates the lymph node found in the 4th mammary gland. (I) Quantification of the ductal length in 55-day old (D55) and 75-day old (D75) mice. *** indicates p < 0.001 and **** indicates p < 0.0001.