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. 2021 Sep 13;9:714330. doi: 10.3389/fcell.2021.714330

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Copyright © 2021 Jeong and Jho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of LRP6 phosphorylation. Phosphorylation of LRP6 can be regulated by various proteins through distinct mechanisms. PTH interacts with the extracellular domain of LRP6 and facilitates its phosphorylation. In contrast, Wnt5a and PEDF interact with the extracellular domain of LRP6 and inhibit LRP6 phosphorylation. GRK5/6, MAPKs, and RTKs facilitate phosphorylation of LRP6 in the cytoplasm, and Lypd6 facilitates phosphorylation of LRP6 in the plasma membrane. Src and Fer and Merlin inhibit phosphorylation of LRP6 in the cytoplasm. Gβ₁γ₂ and TMEM198 promote phosphorylation of LRP6 in GSK3 and CK1-dependent manners, respectively. Arf1/6 facilitates the phosphorylation of LRP6 in a PIP₂-dependent manner.