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. 2021 Sep 13;8:733080. doi: 10.3389/fmed.2021.733080

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Copyright © 2021 Storgaard, Tran, Freiberg, Hauser and Kolko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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New compounds represented in all included trials. Each compound is categorized as IOP-lowering (light green), vascular (orange) or neuroprotective (dark green). The compound is linked to its target. The targets are listed to the right and visualize how some compounds act on several targets. For example: (1) Trabodenoson is an IOP-lowering compound that targets adenosine receptor A1; (2) Clonidine is a vascular compound targeting six different alpha-adrenergic receptors (1A, 1B, 1D, 2A, 2B, and 2C); (3) Insulin is a neuroprotective compound that acts on insulin receptor, insulin-like growth factor 1 receptor, retinoblastoma-associated protein, and carboxypeptidase E.