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. 2021 Sep 13;8:733080. doi: 10.3389/fmed.2021.733080

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Copyright © 2021 Storgaard, Tran, Freiberg, Hauser and Kolko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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New compounds classified as supplements, stimulants, or transplant identified in all included trials. Each compound is categorized as IOP-lowering (light green), vascular (orange), or neuroprotective (dark green). The compound is linked to its target. The targets are listed to the right and visualize how some compounds act on several targets. For example, forskolin is an IOP-lowering compound that targets adenylate cyclase type 2, G(s) subunit alpha-isoforms short, and adenylate cyclase type 5. Only one group of vascular compounds, namely antioxidants, that act on free radicals, is represented.