Figure 4.

New compounds in ongoing trials, trials completed within 2 years and compounds resulting in recently approved glaucoma treatment drugs. The compounds are linked to the target family listed on the right site. The three colors indicate whether a compound is categorized as neuroprotective (dark green), vascular (orange), or IOP-lowering (light green). For example: (1) Omidenepag Isopropyl, a prostaglandin analog, has been approved and works by lowering IOP; (2) ANX007 is a neuroprotective monoclonal antibody c1q and trials with this compound have been completed; (3) Sildenafil is a phosphodiesterase inhibitor that acts on the microvascular blood flow and trials are still ongoing.