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. 2021 Sep 13;12:696840. doi: 10.3389/fgene.2021.696840

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Copyright © 2021 Liu, Chen, Zhang, Wang, Yang, Hai, Wei, Qiao and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential methylation analysis showed that the number of hypomethylation sites in ART-conceived infants was significantly higher than the number of hypermethylation sites. (A) Distribution of differences in DNA methylation levels between the two groups of infants. (B) The ratio of sites with hypomethylation differences and hypermethylation differences was 59:41. Distribution of methylation levels at different sites of hypomethylation (C) and hypermethylation (D). (E) tSNE analysis of differentially methylated sites (DMSs).