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. 2021 Sep 13;12:648420. doi: 10.3389/fimmu.2021.648420

Figure 5.

Figure 5

Highly exhausted HBV-specific CD8 T cells do not respond to PD-L1 blockade. Frequency of HBV-specific (core and/or pool) CD8 T cells with phenotype consistent with low exhaustion (LAG3-TIM3-PD-1+PD-L1-; 1+ markers); intermediate exhaustion LAG3-TIM3+PD-1+PD-L1±; 2+/3+ markers) and high exhaustion (LAG3+TIM3+PD-1+PD-L1+; 4+ markers) between responders (R) and non-responders (NR) to PD-L1 blockade shown as (A) SPICE analysis. *p < 0.05; Permutation test, (B) SPICE CoolPlot and (C) pooled data. Mann Whitney U.