Figure 4.

Cerium (III) chloride (CeCl₃)-loaded mesoporous silica (CeCl₃@mSiO₂) nanoparticles. A type of cerium (III) chloride (CeCl₃)-loaded mesoporous silica (CeCl₃@mSiO₂) nanoparticles designed and to prevent the formation of diabetic cataract in vitro and in vivo using a well-established rat model of streptozotocin-induced diabetes. (A) Schematic diagram of CeCl₃@mSiO₂ nanoparticle preparation; (B) The morphology of the mSiO₂ nanoparticles under transmission electron microscopy (spherical, uniform and monodisperse morphology with an average diameter of 85 nm); (C) A line graph, showing the time course of changes in the cataract degrees in different groups of animals; (D) various degrees of cataract and representative images of H&E-stained sections of the lens tissue in experimentally induced diabetic animals 8 weeks after treatment with vehicle or 10 and 20 mg/kg CeCl₃@mSiO₂ nanoparticles, respectively. Reprinted from Nanomed, 13, Yang J, Gong X, Fang L, et al. Potential of CeCl3@mSiO2 nanoparticles in alleviating diabetic cataract development and progression, 147–1155, Copyright 2017, with permission from Elsevier.¹¹⁰