Table 5.
Nanocarriers to Deliver Anti-Uveitis Agents
| Study | Experimental Models | Drug | Vehicle/Carriers | Production Method(s) | Results | Conclusion |
|---|---|---|---|---|---|---|
| Nikita, et al132 2021 | Unspecified | Everolimus | PVCL-PVA-PEG nanomicellar | Unspecified | Have high encapsulation efficiency and sustained release of everolimus; have higher permeation across goat cornea than everolimus suspension. | Everolimus nanomicelles could be considered a promising topical drug delivery nanocarrier for treating uveitis. |
| Garg V, et al188 2021 | Endotoxin-Induced Uveitis in Rabbit | Tacrolimus | Proglycosome nano-vesicles | Propylene glycol modified lipid vesicles | PNV treatment not only subsides clinical symptoms of uveitis but also prevents breakdown of blood aqueous barrier. | Tacrolimus loaded PNVs are a potential new topical treatment for uveitis. |
| Gaballa SA, et al134 2020 | Rabbits’ model | Beclomethasone Dipropionate | Cubosomes/Cubosomal Gels | Top-down technique | Transcorneal permeation parameters Papp, flux and AUC0-10h, were markedly enhanced up to 4-, 5.8-and 5.5-fold, respectively. | Cubosomes/Cubo-gel could be an auspicious ocular delivery system for BDP that was able to effectively treat uveitis. |
| Nirbhavane P, et al131 2020 | LPS induced inflamed cells | Triamcinolone acetonide | Cationic nanostructured lipid carriers | Hot microemulsion method | Sustained release effects in vitro; no cytotoxicity; retained inside the cells for 24 h; reduced the TNF-α level in LPS induced inflamed cells. | cTA-NLC could be a promising option for the topical treatment of uveitis. |
| Coburn PS, et al189 2019 | A murine sterile endophthalmitis model | Gatifloxacin | Rabbit nanosponges | Biomimetic erythrocyte-derived nanosponge | Reduced the hemolytic activity of a diverse array of PFTs; human nanosponges alone protected mouse retinas following intraocular infection with E. faecalis and S. pneumoniae but not B. cereus or MSSA. | Clinical improvements in intraocular infections following nanosponge treatment were dependent on the complexity and types of toxins produced. Nanosponges might serve as an adjunctive therapy for the treatment of ocular infections. |
| Chennamaneni SR, et al190 2013 | New Zealand White (NZW) rabbits | Dexamethasone | PLGA nanoparticles | Standard oil-in-water (o/w) emulsion-solvent extraction method | DXM flow was bidirectional in the endocapsular space and it was found in the anterior and posterior chambers after up to 6 weeks after WHAT?. | The feasibility of drug delivery from the capsular bag to the anterior and posterior segments effectively compared to topical alternatives. |
| Elbialy NS, et al191 2013 | Male New Zealand white rabbits | Prednisolone acetate | Liposomes | Film hydration method | Have higher entrapment efficiency and slower release rate; higher concentration of PSA in aqueous humor. | pSUV and pMLV are effective carriers for PSA and have a good potential as drug delivery systems in the ocular therapy |