Table 6.
Correlation of illness duration and HDRS score with cortical thickness in patients with BD
| Cortical regions | Illness duration (months) |
HDRS |
|||
|---|---|---|---|---|---|
| R | P | R | P | ||
| Left hemisphere | |||||
| L Frontomarginal gyrus | -0.153 | 0.207 | -0.221 | 0.729 | |
| L Inferior occipital gyrus | -0.014 | 0.911 | -0.234 | 0.198 | |
| L Subcentral gyrus | 0.049 | 0.687 | -0.203 | 0.860 | |
| L Transverse frontopolar gyrus | -0.094 | 0.437 | -0.109 | 0.600 | |
| L Anterior cingulate gyrus | -0.034 | 0.782 | -0.390 | 0.138 | |
| L Anterior mid-cingulate gyrus | 0.008 | 0.950 | -0.294 | 0.235 | |
| L Dorsal posterior cingulate gyrus | 0.020 | 0.871 | -0.362 | 0.193 | |
| L Ventral posterior cingulate gyrus | 0.047 | 0.702 | -0.350 | 0.115 | |
| L Cuneus | -0.082 | 0.498 | 0.240 | 0.502 | |
| L Pars opercularis | 0.045 | 0.712 | -0.181 | 0.621 | |
| L Pars orbitalis | -0.050 | 0.679 | -0.199 | 0.334 | |
| L Pars triangularis | 0.068 | 0.578 | -0.147 | 0.810 | |
| L Short insular gyrus | 0.096 | 0.432 | -0.235 | 0.609 | |
| L Middle occipital gyrus | 0.094 | 0.437 | -0.323 | 0.123 | |
| L Lateral occipito-temporal gyrus | 0.141 | 0.244 | -0.272 | 0.319 | |
| L Lingual gyrus | -0.088 | 0.469 | 0.246 | 0.445 | |
| L Parahippocampal gyrus | 0.021 | 0.865 | -0.298 | 0.088 | |
| L Angular gyrus | 0.066 | 0.588 | -0.192 | 0.711 | |
| L Supramarginal gyrus | 0.122 | 0.313 | -0.310 | 0.152 | |
| L Superior parietal lobule | 0.166 | 0.169 | -0.181 | 0.820 | |
| L Precentral gyrus | 0.100 | 0.411 | -0.266 | 0.135 | |
| L Subcallosal gyrus | -0.120 | 0.323 | -0.281 | 0.108 | |
| L Anterior transverse temporal gyrus | -0.090 | 0.458 | 0.268 | 0.159 | |
| L Planum polare | 0.058 | 0.633 | -0.252 | 0.748 | |
| L Middle temporal gyrus | 0.061 | 0.617 | -0.277 | 0.413 | |
| Right hemisphere | |||||
| R Frontomarginal gyrus | 0.144 | 0.234 | 0.107 | 0.378 | |
| R Inferior occipital gyrus | 0.034 | 0.778 | -0.077 | 0.527 | |
| R Subcentral gyrus | 0.036 | 0.769 | -0.161 | 0.184 | |
| R Transverse frontopolar gyrus | 0.001 | 0.996 | 0.161 | 0.183 | |
| R Anterior cingulate gyrus | -0.027 | 0.825 | -0.010 | 0.937 | |
| R Anterior mid-cingulate gyrus | 0.101 | 0.404 | -0.228 | 0.058 | |
| R Dorsal posterior cingulate gyrus | 0.258 | 0.031 | -0.030 | 0.804 | |
| R Ventral posterior cingulate gyrus | 0.022 | 0.853 | -0.089 | 0.464 | |
| R Cuneus | -0.064 | 0.599 | 0.106 | 0.382 | |
| R Pars opercularis | -0.084 | 0.491 | -0.032 | 0.790 | |
| R Pars orbitalis | -0.006 | 0.959 | -0.063 | 0.603 | |
| R Pars triangularis | -0.115 | 0.344 | 0.108 | 0.373 | |
| R Middle frontal gyrus | 0.007 | 0.957 | 0.027 | 0.827 | |
| R Middle occipital gyrus | 0.109 | 0.367 | -0.121 | 0.320 | |
| R Lateral occipito-temporal gyrus | 0.040 | 0.740 | -0.138 | 0.255 | |
| R Lingual gyrus | -0.070 | 0.563 | 0.136 | 0.263 | |
| R Parahippocampal gyrus | 0.132 | 0.277 | -0.176 | 0.144 | |
| R Orbital gyrus | 0.016 | 0.895 | 0.002 | 0.985 | |
| R Angular gyrus | -0.055 | 0.650 | -0.075 | 0.540 | |
| R Supramarginal gyrus | 0.028 | 0.815 | -0.171 | 0.157 | |
| R Superior parietal lobule | 0.154 | 0.202 | -0.110 | 0.366 | |
| R Precentral gyrus | 0.031 | 0.801 | -0.075 | 0.539 | |
| R Planum polare | 0.058 | 0.631 | -0.171 | 0.156 | |
| R Middle temporal gyrus | 0.071 | 0.557 | -0.055 | 0.652 | |
A two-tailed Pearson’s partial correlation analysis was performed that controlled for age, sex, educational level, and intracranial volume. The 49 cortical regions that remained significant after Bonferroni correction are listed (corrected p=[0.05/49]=1.02×10-3). BD, bipolar disorder; HDRS, Hamilton Depression Rating Scale