Table 7.

Correlation of illness duration and HDRS score with cortical surface areas in patients with BD

Cortical regions		Illness duration (months)		HDRS
		R	P	R	P
Left hemisphere
	L Pars orbitalis	-0.002	0.990	-0.111	0.359
	L Long insular gyrus	-0.076	0.531	-0.250	0.037
Right hemisphere
	R Frontomarginal gyrus	-0.174	0.149	-0.007	0.956
	R Subcentral gyrus	0.098	0.419	0.085	0.483
	R Transverse frontopolar gyrus	-0.065	0.593	-0.008	0.945
	R Anterior cingulate gyrus	-0.009	0.938	-0.164	0.174
	R Posterior mid-cingulate gyrus	0.035	0.774	-0.195	0.106
	R Ventral posterior cingulate gyrus	-0.071	0.561	0.043	0.725
	R Cuneus	0.066	0.586	-0.020	0.868
	R Pars opercularis	0.204	0.091	-0.162	0.181
	R Pars orbitalis	-0.152	0.210	0.098	0.420
	R Pars triangularis	-0.080	0.510	0.096	0.430
	R Middle frontal gyrus	-0.118	0.329	0.161	0.184
	R Superior frontal gyrus	0.079	0.517	-0.071	0.559
	R Long insular gyrus	-0.064	0.596	-0.292	0.014
	R Short insular gyrus	-0.123	0.310	0.044	0.718
	R Superior occipital gyrus	-0.001	0.991	0.104	0.393
	R Lingual gyrus	0.102	0.399	-0.006	0.959
	R Parahippocampal gyrus	-0.114	0.349	0.115	0.344
	R Precuneus	0.050	0.678	0.026	0.829
	R Straight gyrus	0.037	0.758	-0.145	0.232
	R Anterior transverse temporal gyrus	-0.084	0.489	0.084	0.490
	R Lateral superior temporal gyrus	0.108	0.373	-0.116	0.337
	R Planum temporale	-0.108	0.375	0.071	0.557

A two-tailed Pearson’s partial correlation analysis was performed that controlled for age, sex, educational level, and intracranial volume. The 24 cortical regions that remained significant after Bonferroni correction are listed (corrected p=[0.05/24]=2.08×10^-3). BD, bipolar disorder; HDRS, Hamilton Depression Rating Scale