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. 2021 Sep 13;12:725511. doi: 10.3389/fpsyt.2021.725511

Table 4.

ROC analysis of serum t-tau and YKL-40 compared between mild dementia (MD), moderate to severe dementia (MSD), and control group.

Comparison AUC 95% CI P Cut-off Sensitivity% 95% CI Specificity% 95% CI
t-tau
C vs. MD 0.8488 0.7553–0.9423 <0.0001 >341.4 72.09 57.31–83.25% 70 48.10–85.45%
C vs. MSD 0.7294 0.5613–0.8975 0.0174 >324.8 64.71 41.30–82.69% 65 43.29–81.88%
MD vs. MSD 0.6607 0.5114–0.8101 0.0539 <377.9 58.82 36.01–78.39% 58.14 43.33–71.62%
YKL-40
C vs. MD 0.9128 0.8412–0.9843 <0.0001 >115.8 86.05 72.74–93.44% 85 63.96–94.76%
C vs. MSD 0.6471 0.4692–0.8249 0.1276 >90.60 52.94 30.96–73.83% 55 34.21–74.18%
MD vs. MSD 0.8263 0.7067–0.9458 <0.0001 <123.3 76.47 52.74–90.44% 76.74 62.26–86.85%