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FHL2 functional model in Bzb-induced osteoblast differentiation of MM-MSCs. P53 degradation is weakened with proteasome inhibition by Bzb. Upregulated p53 binds to the binding motifs in the promoter region of the FHL2 gene and promotes FHL2 expression. Finally, increased FHL2 changes subcellular localization of β-catenin (nuclear enrichment) and promotes osteogenic differentiation of MM-MSCs.
